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Who Needs Extra Caution and When to Reassess Dosing Patients with baseline systolic blood pressure under 120 mmHg, those on three or more antihypertensive agents, or those with kidney disease or heart failure should discuss GLP-1 use more thoroughly with their provider before starting

Pregnancy and lactation: NAC has been used in obstetric protocols for acetaminophen overdose and recurrent pregnancy loss with reasonable safety data

Estimates suggest that around 60% of people with severe mental disorders are living with overweight or obesity

Patients with existing heart or kidney disease may benefit from starting SGLT-2 inhibitors therapy, while those with a higher risk of developing these conditions, such as obese patients and those with no cardiogenic stroke, may benefit more from GLP-1 RAs